Pоpulаtiоn replаcement strаtegy by using transgenic/mоdified mosquitoes is a very promising tool as a definitive solution against mosquito-borne pathogens. The scientific community has been advancing the technology since the proof of concept was achieved in the laboratory. However, some limitations and technical problems must be overcome before this approach can become a reality. Which of the following are the most important challenges that must be addressed before this approach becomes feasible?