Elenа Mоrаles, аge 56, has a histоry оf chronic gastroesophageal reflux, tobacco use, and obesity. She reports progressively worsening difficulty swallowing, fatigue, and unintentional weight loss. Endoscopy reveals areas of altered esophageal epithelium consistent with Barrett’s esophagus. Biopsy findings include abnormal cellular size, shape, and organization. A second tissue sample identifies a poorly differentiated esophageal adenocarcinoma that has invaded adjacent tissue. Tumor sequencing identifies a mutation found only in the tumor cells. Separate genetic testing identifies a germline cancer-susceptibility variant that follows an autosomal dominant inheritance pattern. Elena undergoes surgery to remove the tumor. On postoperative day 5, the incision is red, warm, swollen, and draining purulent material. Elena has a temperature of 101.84°F. A culture identifies Staphylococcus aureus (Staph aureus). The wound later heals.