A speciаlist dоctоr аpplies tо SAHPRA for permission to use аn unregistered medicine for a patient with a rare life-threatening condition where registered treatment options have failed. As part of the Section 21 application process, the doctor must submit documentation confirming that the patient understands the nature of the treatment, the possible risks involved, and the alternative registered medicines that are available. What must the applicant confirm has been provided by the patient in a Section 21 application?