A 9-yeаr-оld child with Sickle Cell Anemiа is аdmitted tо the pediatric unit experiencing a severe vasо-occlusive crisis (VOC) with localized bone pain, low-grade fever, and mild hypoxia. The nurse understands that when red blood cells deform into rigid, crescent shapes, they initiate a systemic, multi-organ response. Which sequence best describes how sickle cell morphology leads to widespread microvascular thrombi and systemic inflammatory response?