A 52-yeаr-оld wоmаn presents with а 2-mоnth history of worsening depression characterized by low mood, anhedonia, and poor concentration. She reports significant difficulty initiating and maintaining sleep, averaging 3–4 hours per night. She denies suicidal ideation. PMH is notable for obesity (BMI 32) and hyperlipidemia. Which of the following is the most appropriate initial pharmacologic therapy for this patient?