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In the grаph shоwn belоw, whаt is the independent vаriable?
There аre FIVE questiоns frоm which yоu аre required to аnswer THREE; additional answers will not be marked. There are 3 answer boxes below this box. Each answer box MUST be used to answer one of the questions you select. Please also remember to tell us which question you are answering. See the example below: 'This is my answer to Question 1...' Questions are as followed...: Question 1: (Answer all parts of the question) A 72-year old woman has a full blood count checked as part of an investigation following a visit to her GP complaining of a swelling in her neck and lack of energy. On the blood film, numerous small lymphocytes were observed and the full blood count shows: Abbreviations: MCV, mean cell volume; MCH, mean cell haemoglobin. a) Using a differential diagnostic approach, interpret the patient signs and symptoms along with the laboratory data to develop a diagnosis for the patient. (60%) b) Identify which further laboratory tests you would use to confirm the diagnosis and explain why. (40%) Question 2: (Answer all parts of the question) a) Explain how the red blood cell membrane is organised to allow reversible deformation (20%) b) Compare and contrast the pathophysiology of Hereditary Spherocytosis and G6PD Deficiency (include in your answer examples of typical laboratory findings for patients with these conditions) (80%) Question 3: Compare and contrast the four main types of leukaemia (include in your answer symptoms, common genetic abnormalities, and examples of typical laboratory findings) (100%) Question 4: (Answer all parts of the question) A woman is brought into A&E after being a passenger in a minor road traffic accident. She is 36 weeks pregnant (36/40 weeks gestation) with her first child, and blood testing reveals the presence of anti-D in the patient’s plasma. Her previous medical notes (from 12/40 weeks gestation) say her blood group is O Rh(D) negative, with no atypical blood group antibodies. a) Describe the test used to screen clinically significant antibodies in patient plasma (20%) b) Explain the likely reason for and discuss the significance of the presence of anti-D antibody in this patient (30%) c) Discuss the pathophysiology of haemolytic disease of the fetus/newborn (50%) Question 5: (Answer all parts of the question) Compare and contrast the clinical significance of antibodies in the ABO blood group system to those of the other clinically significant blood group systems (Rh, Duffy, Kidd etc). (100%)