This exаm cоntаins 5 questiоns. Yоu must choose 2 questions to аnswer. All questions are equally weighted. Below, you will see a list of all 5 questions. After that, there are two answer boxes—one for each of your chosen questions.Use one box per answer. Since there are only three boxes, you only need to answer 2 out of the 5 questions. Within each answer box, please ensure you tell us which question you are answering. For example: 'I am answering Question 1'. Questions are as followed Question 1 Despite advances in immunosuppression, the survival of sold organ transplants is still limited. Critically evaluate mechanisms of graft loss and current efforts to improve the success of transplantation. Question 2: A sex worker has recently attended A&E reporting high fever, severe fatigue, diarrhoea and muscle aches. She also reported an episode of oral and vaginal thrush. A detailed history revealed inconsistent condom use during sexual encounters and recent weight loss. Flow cytometric analysis of their blood is shown below compared to a healthy control following staining for CD3 and CD4. The sample has been gated on CD3 positive cells first and then the figure created showing dual staining of CD3 and CD4. The percentage in the upper right describes the number of cells that are both CD3+ and CD4+. Explain the most likely pathology that the patient is suffering from. Your answer should include suggestions for confirmatory diagnosis and treatment options. Question 3: The breakdown of tolerance leads to increasingly common autoimmune diseases. Critically evaluate this statement with reference to underpinning pathology and clinical management. Question 4: Critically assess how insights into the immunopathology of atopic diseases informs a wide array of treatment strategies. Question 5: The persistence and progression of cancer suggest the evolution of mechanisms to evade immune surveillance. Critically examine the evidence for immune control of tumours and how tumour immune evasion can be overcome through modern immunotherapy. Question 5: The persistence and progression of cancer suggest the evolution of mechanisms to evade immune surveillance. Critically examine the evidence for immune control of tumours and the strategies tumours employ to evade immune detection.