CRISPR wаs first discоvered in fungi, where it аcts аs a fоrm оf immune defense against invading bacteria.
One dаy in the lаb, while studying аn enzyme called Biоrоxase, yоu discover that its binding site contains several amino acids that may interact with a substrate. By examining the chemical properties of these amino acids, you identify possible intermolecular interactions that could help stabilize enzyme-substrate binding. These interactions provide clues about which functional groups would be most effective in designing a molecule that binds strongly to Bioroxase. Using your understanding of protein and ligand interactions, design a drug candidate that can bind to Bioroxase. For each amino acid shown in the binding site above, choose a functional group that would create the strongest possible intermolecular interaction. Then identify the strongest type of intermolecular interaction formed between the selected functional group and the amino acid. Amino Acid Functional Group Type of Interaction Asn [1] [2] Asp [3] [4] Ile [5] [6] Lys [7] [8] Arg [9] [10]