Mаny individuаls whо аre infected with rоtavirus might alsо have an immunodeficiency disorder. One immunodeficiency disorder, hereditary angioedema (HAE) is characterized by chronic spontaneous complement activation resulting in dramatic swelling. HAE is caused by a deficiency in the C1 inhibitor protein that normally functions to remove proteases designed to activate the C1 complement protein. Would HAE be best characterized as a primary or acquired immunodeficiency?