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A 60 yeаr оld wоmаn hаs a histоry of hypertension which has been poorly controlled. Her GFR has been consistently low for the past 6 months and is currently 40 mL/min/1.73 m2. (Stage 3B) 1- The GFR is a measure of? (1 point) 2- While hypertension and diabetes mellitus are disorders that often lead to CKD, describe the 2 key underlying pathophysiological factors that lead to CKD development and progression. (2 points) 3- There are many systemic manifestations that are evident in CKD- PICK ONLY 2 BELOW AND briefly describe (one sentence) the why for each of the following manifestations: (DO NOT ANSWER MORE THAN 2)-- (2 points) Pruritus hypertension Heart failure Increased bleeding time, thrombosis risk Bone pain/fractures, muscle weakness hyperkalemia