NF-kB is a transcription factor that plays an important role…

Written by Anonymous on September 6, 2024 in Uncategorized with no comments.

Questions

NF-kB is а trаnscriptiоn fаctоr that plays an impоrtant role in the inflammatory response. Under normal conditions, NF-kB is inactive because it is sequestered in the cytoplasm by interaction with the inhibitory protein I-kB. Activation of NF-kB requires the phosphorylation and subsequent degradation of I-kB.  The I-kB kinase, IKK, is the enzyme responsible for this phosphorylation.  IKK has two substrates, I-kB and ATP, and produces two products, I-kB -P and ADP.  It has been found that IKK follows the reaction mechanism shown below.  This mechanism is known as _______.

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